NORMAL

Aneusomic interphase cell obtained from a sample showing two copies of chromosome 3 (red), four copies of chromosome 7 (green), five copies of chromosome 17 (aqua) and one copy of p16 gene (gold) after the UroVysion Bladder Cancer Kit (UroVysion Kit) hybridization.

ABNORMAL

LSI BCL6 (ABR) Dual Color, Break Apart Rearrangement Probe hybridized to a nucleus with a translocation breakpoint involving the BCL6 gene showing a one orange, one green, one fusion (1O1G1F) pattern.

NORMAL

ABNORMAL

Vysis LSI RPN1/MECOM Dual Color Dual Fusion Probes hybridized to a nucleus containing a simple balanced t(3;3)(q21.3;q26.2). One orange, one green and two orange/green fusion signals are observed. The most frequently expected signal pattern of the Vysis LSI RPN1/MECOM Dual Color Dual Fusion Probes in abnormal specimens is 1 orange, 1 green, and 2 orange/green fusion signals. Other signal patterns may occur in abnormal specimens, and metaphase analysis may be helpful in characterization of such patterns. 

NORMAL

Vysis LSI RPN1/MECOM Dual Color Dual Fusion Probes hybridized to a nucleus containing non-rearranged RPN1 and MECOM regions. Two orange and two green signals are observed. The most commonly expected signal pattern of the Vysis LSI RPN1/ MECOM Dual Color Dual Fusion Probes in normal specimens is 2 orange and 2 green signals. Due to the proximity of the 2 probes on the q arm of chromosome 3, however, the orange and green signals may sometimes appear as a fusion in a normal nucleus. This effect can produce a pattern of 1 orange, 1 green, and 1 orange/green fusion signal or, more rarely, 2 orange/green fusion signals.