NORMAL

Analysis of an uncultured amniocyte (sometimes referred to as direct analysis) hybridized with the AneuVysion 18/X/Y probe set. Three aqua signals indicate three copies of chromosome 18, one green signal indicates one copy of the X chromosome and one orange signal indicates one copy of the Y chromosome.

ABNORMAL

Abnormal cells hybridized with the Vysis LSI FOXO1 (13q14) Dual Color Break Apart Rearrangement Probe. The cell in this image shows fusion, orange and green signals suggesting rearrangement of the FOXO1 gene region. The extra signals in the cell suggest aneuploidy.In a normal cell that lacks a t(13q14) in the FOXO1 gene region, a two fusion signal pattern will be observed.

NORMAL

Result of the hybridization of the Vysis LSI FOXO1 (13q14) Dual Color Break Apart Rearrangement Probe, showing the two fusion signal pattern as observed in normal interphase cells. In a normal cell that lacks a t(13q14) in the FOXO1 gene region, a two fusion signal pattern will be observed. 

ABNORMAL

LSI 13 (13q14) SpectrumGreen hybridized to an amniocyte.  Three green signals indicate three copies of chromosome 13

NORMAL

LSI 13 (RB1) 13q14 Probe hybridized to a normal nucleus showing a two orange (2O) signal pattern.In a normal cell, the expected result for a nucleus hybridized with the LSI 13 (RB1) probe is a two orange (2O) signal pattern. In a hybridized abnormal cell containing the deletion, a one orange (1O) signal pattern will be observed.

Result of the hybridization of the LSI 13q34 Probe as observed in a normal interphase cell.In a normal cell with two intact copies of chromosome 13, two green signals will be observed.

ABNORMAL

Abnormal cell hybridized with the LSI 13q34 Probe. The cell in this image shows deletion of one copy of the 13q34 region of chromosome 13 as indicated by the single green signal.In an abnormal cell that has lost the 13q34 region of chromosome 13, fewer than two green signals will be observed.