NORMAL

Analysis of an uncultured amniocyte (sometimes referred to as direct analysis) hybridized with the AneuVysion 18/X/Y probe set. Three aqua signals indicate three copies of chromosome 18, one green signal indicates one copy of the X chromosome and one orange signal indicates one copy of the Y chromosome.

NORMAL

Normal cell hybridization using the LSI BCL2 Dual Color Break Apart Rearrangement Probe

ABNORMAL

NORMAL

ABNORMAL

LSI IGH/BCL2 Dual Color, Dual Fusion Translocation Probe hybridized to a nucleus containing the t(14;18) (q32;q21) showing the 1O1G2F signal pattern.The expected pattern in a normal nucleus hybridized with the LSI IGH/BCL2 probe is the two orange, two green signal pattern (2O2G). In a nucleus harboring a t(14;18), the most common pattern is one orange signal, one green signal (representing the normal homolog) and two orange/green (yellow) fusion signals representing the two derivative chromosomes resulting from the reciprocal translocation (1O1G2F pattern). Patterns other than 1O1G2F may be observed in some abnormal cells including instances of nuclei containing more than two fusion signals.

ABNORMAL

LSI IGH/BCL2 Dual Color, Dual Fusion Translocation Probe hybridized to a nucleus containing the t(14;18) (q32;q21) showing the 1O1G2F signal pattern.The expected pattern in a normal nucleus hybridized with the LSI IGH/BCL2 probe is the two orange, two green signal pattern (2O2G). In a nucleus harboring a t(14;18), the most common pattern is one orange signal, one green signal (representing the normal homolog) and two orange/green (yellow) fusion signals representing the two derivative chromosomes resulting from the reciprocal translocation (1O1G2F pattern). Patterns other than 1O1G2F may be observed in some abnormal cells including instances of nuclei containing more than two fusion signals.

ABNORMAL

Cell hybridized with the LSI IGH/MALT1 t(14;18)(q32;q21) Dual Color, Dual Fusion Translocation Probe. The cell in this image shows the one orange, one green and two fusion signal pattern.

NORMAL

Result of the hybridization of the LSI IGH/MALT1 t(14;18)(q32;q21) Dual Color, Dual Fusion Translocation Probe as observed in interphase cells.

ABNORMAL

An abnormal cell hybridized with the Vysis LSI MALT1 Dual Color Break Apart Rearrangement Probe. The cell in this image shows the one fusion, one orange, and one green signal pattern indicative of a rearrangement of one copy of the MALT1 gene region.In an abnormal cell with a t(18q21), a one fusion, one green, one orange signal pattern will be observed.

NORMAL

Result of the hybridization of the Vysis LSI MALT1 Dual Color  Break Apart Rearrangement Probe as observed in three normal interphase cells.In a normal cell that lacks a t(18q21) in the MALT1 gene region, a two fusion signal pattern will be observed reflecting the two intact copies of MALT1.