血液学探针设计

Vysis DNA FISH 探针的独特设计为检测与造血功能障碍相关的关键遗传畸变提供了明显的优势。针对与这些疾病相关的染色体易位的 Vysis DNA FISH 探针设计的独特类型描述如下:

双色,单融合

适用于检测具有特定染色体易位的细胞出现频率较高的样本。DNA 探针杂交靶标分别位于两个基因断点的一侧。由于正常细胞核中探针信号的随机共定位,ES(额外信号)能够使正常细胞表现出异常 FISH 模式的频率降低。一个大型探针跨越一个断点,而另一个探针位于另一个基因断点一侧。

双色,分离

在可能存在与已知基因断点相关的多个易位伴侣的情况下有用。该标记方案的特点是,两种不同颜色的探针可分别与一个基因中某个断点两端上的靶标杂交。

双色,双融合

极大地减少了呈现异常信号模式的正常细胞核的数量。最适用于检测具有简单平衡易位的细胞核出现频率较低的样本。两种大型探针可分别跨越不同染色体上的两个断点。

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