Vysis ToTelVysion 探针试剂盒

CE 标志

供体外诊断使用

Vysis ToTelVysion 探针试剂盒由 41 个 TelVysion 探针组成,包括多种 LSI 和 CEP 探针(总共 64 个探针)。

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描述
 

41 个 TelVysion 探针具体用于:

  •  染色体 1 - 12 和 16 - 20 的 p 和 q 亚端粒
  • 近端着丝粒染色体(13、14、15、21 和 22)的 q 亚端粒
  • Xp/Yp 和 Xq/Yq 拟常染色体区域亚端粒
  • 每个染色体端粒 300 kb 内的独特区域

ToTelVysion 中的探针以 15 种混合物的形式提供。所有探针均为直接标记,以在最小背景噪声下提供明亮的信号。通过利用 SpectrumOrange、SpectrumGreen、SpectrumAqua,以及 SpectrumOrange 和 SpectrumGreen 的组合(以产生黄色信号),混合物中的每个探针均以唯一的颜色标记。

 

Vysis TelVysion 探针

端粒是覆盖真核生物染色体末端的 DNA-蛋白质复合物。每个端粒包含 3 到 20 kb 串联 TTAGGG 重复序列。端粒相关重复序列 (TAR),也称为亚端粒重复序列,紧邻 TTAGGG 重复序列。其包含某些染色体子集之间具有同源性的区域。每个 TelVysion 靶向位点是一个独特的染色体特异性 DNA,位于距染色体末端约 100 至 300 kb 处。

 

人类染色体端粒区组成示意图

人类染色体端粒区组成示意图
在体构性染色体分析的背景下,染色体臂上唯一 DNA 的最远端区域通常被称为“亚端粒”。与其他染色体区域相比,已知亚端粒区域含有大量基因。然而,如果并非不可能,通过常规 G 带分析很难检测到亚端粒异常,因为亚端粒染色通常为阴性(轻)。图表由芝加哥大学 C. Lese 和 D. Ledbetter 提供。

探针信息

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